Now on this evening’s reading list: Bioavailability and bioeffectiveness of subcutaneous human insulin and two of its analogs—LysB28ProB29-human insulin and AspB10LysB28ProB29-human insulin—assessed in a conscious pig model. (“LysB28ProB29,” or insulin lispro, is better known as Humalog.) Along with the “Pharmacokinetics” section of the Humalog FDA drug insert, it’s helping me better understand insulin absorption, metabolism, and elimination. My goal is to have a better model of “active insulin” than just insulin on board (IOB) and to look at how insulinized I am at different parts of the day.

The main question I hope to answer is whether having twice as much serum (i.e., blood) insulin concentration means twice as much BG lowering effect. I suspect it does, but as we all know, “Assumption, my dear Mitz, is the mother of all fuck-ups.” [IMDB]

Yesterday evening I estimated some of the information from one of the charts in the Humalog insert, put it into MATLAB, used one of our more awkwardly named functions (cumtrapz), and generated this table:

Those tiny numbers (hopefully) tonight will become a set of overlaid curves that show how much insulin is in my blood throughout the day. Yay, math!

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2 Responses to Pharmacokinetics

  1. Wow, dude! You are taking diabetes smarts to the next level. I do hope that you’ll be sharing your learnings, and maybe even breaking it down into simple language so I can understand. :-)

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